Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus
김재신, 차재국, 이중석, 최성호, 조규성,
소속 상세정보
김재신 ( Kim Jae-Shin ) - Yonsei University College of Dentistry Department of Periodontology
차재국 ( Cha Jae-Kook ) - Yonsei University College of Dentistry Department of Periodontology
이중석 ( Lee Jung-Seok ) - Yonsei University College of Dentistry Department of Periodontology
최성호 ( Choi Seong-Ho ) - Yonsei University College of Dentistry Department of Periodontology
조규성 ( Cho Kyoo-Sung ) - Yonsei University College of Dentistry Department of Periodontology
KMID : 0363020160460050350
Abstract
Purpose: The purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly formed bone in a rabbit maxillary sinus model.
Methods: In 7 rabbits, sinus windows were prepared bilaterally. Biphasic calcium phosphate (BCP) loaded with 0.05 mg/mL BMP-2 was grafted into one sinus (the BMP group) and saline-soaked BCP was placed into the other (the control group) in each animal. The animals were allowed an 8-week healing period before being sacrificed. Specimens including the augmented area and surrounding tissues were then removed and evaluated both radiographically and histologically.
Results: There was a difference in the mineralization of new bone between the groups. In the BMP group, the greater part of the new bone consisted of mature lamellar bone with an evident trabecular pattern, whereas the control group showed mostly woven bone, consisting only partially of lamellar bone. Histometrically, the area of new bone was significantly greater (4.55±1.35 mm2 vs. 2.99±0.86 mm2) in the BMP group than in the control group (P<0.05); however, the total augmentation volumes were not significantly different between the groups.
Conclusions: Within the limitations of this study, it can be suggested that a minimal concentration of BMP-2 (0.05 mg/mL) had an osteoinductive effect with accelerated mineralization in a rabbit sinus model using a BCP carrier.
키워드
Bone morphogenetic proteins; Physiologic calcification; Hydroxyapatite-beta tricalcium phosphate; Sinus floor augmentation
원문 및 링크아웃 정보
등재저널 정보